P-150 Hispanic/Latino patients with metastatic gastric adenocarcinoma: Impact of single metastasis in overall survival

Gastric cancer is one of the leading causes death worldwide. Hispanic/Latino patients, have previously demonstrated to clinicopathological features related a worse prognosis, including high prevalence metastatic disease, young age, more proportion diffuse type cancers and higher rate mortality. Nevertheless, analysis overall survival comparing number metastases among advanced gastric adenocarcinoma remains unclear. The aim this study analyze our population evaluate impact in OS patients with treated at National Cancer Institute. present included diagnosed adenocarcinoma, Institute between 2010 2021. Statistical required: X2 t test, Kaplan Meier, Log Rank Cox Regression. significance differences were assessed when p was bilaterally < 0.05. 1,319 disease. Regarding advanced/metastatic 52% male, an 18% (n=) reported, 60% (n=378) diffuse-type carcinomas. Besides, 75% (n=469) reported signed-ring cells poor differentiation 88% (n=556) 28% (n=376) intestinal type. According sites, (n= 987) only site metastasis, while resting 25% 332) two or sites by time diagnosis. A conducted considering sites; single-metastasis median 11 months versus 8 for (p=0.027, HR 0.78, 95% CI 0.65-0.94). At Multivariate analysis, grade (p=0.002, 1.29, 1.10-1.53), (p=0.029, 0.730 0.55-0.96), metastasis (p=0.023, 0.80, 0.66-0.97) remained as predictors survival. disease high, increasing association bad prognosis. However, single significantly different compared multiple metastasis. multidisciplinary team approaches fundamental assess best treatment option these patients.